6OQY

Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator

6OQY の概要

• エントリーDOI: 10.2210/pdb6oqy/pdb
• 分子名称: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide, ... (4 entities in total)
• 機能のキーワード: nuclear hormone receptor, agonist, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30605.39

構造登録者

Mays, S.G.,Ortlund, E.A. (登録日: 2019-04-29, 公開日: 2019-08-28, 最終更新日: 2023-10-11)

• 主引用文献: Mays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A.; Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.; J.Med.Chem., 62:11022-11034, 2019; PubMed: 31419141; DOI: 10.1021/acs.jmedchem.9b00753

実験手法

X-RAY DIFFRACTION (2.23 Å)