6OOU

Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir

6OOU の概要

• エントリーDOI: 10.2210/pdb6oou/pdb
• 分子名称: NL4-3 PROTEASE, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22375.40

構造登録者

Henes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A.,Whitfield, T.W. (登録日: 2019-04-23, 公開日: 2019-08-21, 最終更新日: 2023-10-11)

• 主引用文献: Henes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A.,Whitfield, T.W.; Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.; Biochemistry, 58:3711-3726, 2019; PubMed: 31386353; DOI: 10.1021/acs.biochem.9b00446

実験手法

X-RAY DIFFRACTION (2.127 Å)