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6OOT

HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir

Summary for 6OOT
Entry DOI10.2210/pdb6oot/pdb
DescriptorNL4-3 PROTEASE, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total)
Functional Keywordshiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22411.48
Authors
Henes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A.,Whitfield, T.W. (deposition date: 2019-04-23, release date: 2019-08-21, Last modification date: 2023-10-11)
Primary citationHenes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A.,Whitfield, T.W.
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry, 58:3711-3726, 2019
Cited by
PubMed: 31386353
DOI: 10.1021/acs.biochem.9b00446
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.822 Å)
Structure validation

217705

数据于2024-03-27公开中

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