6OOS

HIV-1 Protease NL4-3 L90M Mutant in complex with darunavir

Summary for 6OOS

Entry DOI	10.2210/pdb6oos/pdb
Descriptor	NL4-3 PROTEASE, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total)
Functional Keywords	hiv, nl4-3 protease, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	4
Total formula weight	45551.50
Authors	Henes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,KurtYilmaz, N.,Schiffer, C.A.,Whitfield, T.W. (deposition date: 2019-04-23, release date: 2019-08-21, Last modification date: 2023-10-11)
Primary citation	Henes, M.,Kosovrasti, K.,Lockbaum, G.J.,Leidner, F.,Nachum, G.S.,Nalivaika, E.A.,Bolon, D.N.A.,Kurt Yilmaz, N.,Schiffer, C.A.,Whitfield, T.W. Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance. Biochemistry, 58:3711-3726, 2019 Cited by PubMed: 31386353 DOI: 10.1021/acs.biochem.9b00446 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation