6OML

Human BMP chimera BV261

6OML の概要

• エントリーDOI: 10.2210/pdb6oml/pdb
• 分子名称: Bone morphogenetic protein 2 and Bone morphogenetic protein 6, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: bmp, bone morphogenetic protein, cytokine
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24995.24

構造登録者

Seeherman, H.,Juo, Z.S. (登録日: 2019-04-18, 公開日: 2019-05-15, 最終更新日: 2020-07-29)

• 主引用文献: Seeherman, H.J.,Berasi, S.P.,Brown, C.T.,Martinez, R.X.,Juo, Z.S.,Jelinsky, S.,Cain, M.J.,Grode, J.,Tumelty, K.E.,Bohner, M.,Grinberg, O.,Orr, N.,Shoseyov, O.,Eyckmans, J.,Chen, C.,Morales, P.R.,Wilson, C.G.,Vanderploeg, E.J.,Wozney, J.M.; A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.; Sci Transl Med, 11:-, 2019; PubMed: 31019025; DOI: 10.1126/scitranslmed.aar4953

実験手法

X-RAY DIFFRACTION (2.7 Å)