6OJV

Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid

Summary for 6OJV

Entry DOI	10.2210/pdb6ojv/pdb
Descriptor	Thymidylate synthase,Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, ... (4 entities in total)
Functional Keywords	inhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	135642.54
Authors	Czyzyk, D.J.,Anderson, K.S.,Valhondo, M.,Jorgensen, W.L. (deposition date: 2019-04-12, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593:2069-2078, 2019 Cited by PubMed: 31172516 DOI: 10.1002/1873-3468.13474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.593 Å)

Structure validation