6OJV
Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid
Summary for 6OJV
Entry DOI | 10.2210/pdb6ojv/pdb |
Descriptor | Thymidylate synthase,Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 135642.54 |
Authors | Czyzyk, D.J.,Anderson, K.S.,Valhondo, M.,Jorgensen, W.L. (deposition date: 2019-04-12, release date: 2019-06-19, Last modification date: 2023-10-11) |
Primary citation | Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593:2069-2078, 2019 Cited by PubMed: 31172516DOI: 10.1002/1873-3468.13474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.593 Å) |
Structure validation
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