6OJV

Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid

6OJV の概要

分子名称Thymidylate synthase,Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, ... (4 entities in total)
機能のキーワードinhibitor, ts, ts-dhfr, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (Human)
ポリマー鎖数4
分子量合計135642.54
構造登録者
Czyzyk, D.J.,Anderson, K.S.,Valhondo, M.,Jorgensen, W.L. (登録日: 2019-04-12, 公開日: 2019-06-19)
主引用文献
Czyzyk, D.J.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S.
Understanding the Structural Basis of Species Selective, Stereospecific Inhibition for Cryptosporidium and Human Thymidylate Synthase.
Febs Lett., 2019
PubMed: 31172516 (主引用文献が同じPDBエントリー)
DOI: 10.1002/1873-3468.13474
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.593 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26930 1.1% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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