6OIA

(1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase

Summary for 6OIA

Entry DOI	10.2210/pdb6oia/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... (5 entities in total)
Functional Keywords	human ornithine aminotransferase (hoat) mechanism based inhibitors hepatocellular carcinoma plp, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	135980.93
Authors	Catlin, D.S.,Liu, D.,Moschitto, M.J.,Doubleday, P.F.,Kelleher, N.,Silverman, R.B. (deposition date: 2019-04-09, release date: 2019-09-18, Last modification date: 2020-04-01)
Primary citation	Moschitto, M.J.,Doubleday, P.F.,Catlin, D.S.,Kelleher, N.L.,Liu, D.,Silverman, R.B. Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. J.Am.Chem.Soc., 141:10711-10721, 2019 Cited by PubMed: 31251613 DOI: 10.1021/jacs.9b03254 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.777 Å)

Structure validation