6OIA

(1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase

6OIA の概要

• エントリーDOI: 10.2210/pdb6oia/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: human ornithine aminotransferase (hoat) mechanism based inhibitors hepatocellular carcinoma plp, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135980.93

構造登録者

Catlin, D.S.,Liu, D.,Moschitto, M.J.,Doubleday, P.F.,Kelleher, N.,Silverman, R.B. (登録日: 2019-04-09, 公開日: 2019-09-18, 最終更新日: 2020-04-01)

• 主引用文献: Moschitto, M.J.,Doubleday, P.F.,Catlin, D.S.,Kelleher, N.L.,Liu, D.,Silverman, R.B.; Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid.; J.Am.Chem.Soc., 141:10711-10721, 2019; PubMed: 31251613; DOI: 10.1021/jacs.9b03254

実験手法

X-RAY DIFFRACTION (1.777 Å)