6OHT

Structure of EBP and U18666A

Summary for 6OHT

Descriptor3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 3beta-(2-Diethylaminoethoxy)androst-5-en-17-one (2 entities in total)
Functional Keywordsmembrane protein, isomerase, isomerase-inhibitor complex, isomerase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight83850.46
Authors
Long, T.,Li, X. (deposition date: 2019-04-06, release date: 2019-06-19)
Primary citation
Long, T.,Hassan, A.,Thompson, B.M.,McDonald, J.G.,Wang, J.,Li, X.
Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Nat Commun, 10:2452-2452, 2019
PubMed: 31165728 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10279-w
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.319140 3.5% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution