6OGQ

X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-003

Summary for 6OGQ

Entry DOI	10.2210/pdb6ogq/pdb
Descriptor	Protease, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	11764.69
Authors	Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Aoki, M.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2019-04-03, release date: 2020-04-08, Last modification date: 2023-10-11)
Primary citation	Bulut, H.,Hattori, S.I.,Aoki-Ogata, H.,Hayashi, H.,Das, D.,Aoki, M.,Davis, D.A.,Rao, K.V.,Nyalapatla, P.R.,Ghosh, A.K.,Mitsuya, H. Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity. Sci Rep, 10:10664-10664, 2020 Cited by PubMed: 32606378 DOI: 10.1038/s41598-020-65993-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.41 Å)

Structure validation