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6OGN

Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe

Replaces:  6NPG
Summary for 6OGN
Entry DOI10.2210/pdb6ogn/pdb
DescriptorProtein arginine N-methyltransferase 7, ZINC ION, 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, ... (5 entities in total)
Functional Keywordsprmt7, sgc8158, chemical probe, structural genomics, structural genomics consortium, transferase
Biological sourceMus musculus (Mouse)
Total number of polymer chains1
Total formula weight80952.60
Authors
Halabelian, L.,Dong, A.,Zeng, H.,Li, Y.,Hutchinson, A.,Seitova, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Structural Genomics Consortium (SGC) (deposition date: 2019-04-03, release date: 2019-04-17, Last modification date: 2023-10-11)
Primary citationSzewczyk, M.M.,Ishikawa, Y.,Organ, S.,Sakai, N.,Li, F.,Halabelian, L.,Ackloo, S.,Couzens, A.L.,Eram, M.,Dilworth, D.,Fukushi, H.,Harding, R.,Dela Sena, C.C.,Sugo, T.,Hayashi, K.,McLeod, D.,Zepeda, C.,Aman, A.,Sanchez-Osuna, M.,Bonneil, E.,Takagi, S.,Al-Awar, R.,Tyers, M.,Richard, S.,Takizawa, M.,Gingras, A.C.,Arrowsmith, C.H.,Vedadi, M.,Brown, P.J.,Nara, H.,Barsyte-Lovejoy, D.
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Nat Commun, 11:2396-2396, 2020
Cited by
PubMed: 32409666
DOI: 10.1038/s41467-020-16271-z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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