6OFD

The crystal structure of octadecyloxy(naphthalen-1-yl)methylphosphonic acid in complex with red kidney bean purple acid phosphatase

6OFD の概要

• エントリーDOI: 10.2210/pdb6ofd/pdb
• 分子名称: Fe(3+)-Zn(2+) purple acid phosphatase, [(S)-(naphthalen-1-yl)(octadecyloxy)methyl]phosphonic acid, SODIUM ION, ... (17 entities in total)
• 機能のキーワード: purple acid phosphatase, metallohydrolases, transition state, catalysis, osteoporosis, metal binding protein
• 由来する生物種: Phaseolus vulgaris (Kidney bean)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 223835.76

構造登録者

Feder, D.,Schenk, G.,Guddat, L.W.,Hussein, W.M.,McGeary, R.P.,Kan, M.W. (登録日: 2019-03-29, 公開日: 2019-09-04, 最終更新日: 2023-10-11)

• 主引用文献: Feder, D.,Kan, M.W.,Hussein, W.M.,Guddat, L.W.,Schenk, G.,McGeary, R.P.; Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis.; Eur.J.Med.Chem., 182:111611-111611, 2019; PubMed: 31445230; DOI: 10.1016/j.ejmech.2019.111611

実験手法

X-RAY DIFFRACTION (2.2 Å)