6OAH

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02-78

6OAH の概要

• エントリーDOI: 10.2210/pdb6oah/pdb
• 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid, ... (5 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44251.82

構造登録者

Park, J.,Berghuis, A.M. (登録日: 2019-03-16, 公開日: 2019-11-06, 最終更新日: 2023-10-11)

• 主引用文献: Feng, Y.,Park, J.,Li, S.G.,Boutin, R.,Viereck, P.,Schilling, M.A.,Berghuis, A.M.,Tsantrizos, Y.S.; Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).; J.Med.Chem., 62:9691-9702, 2019; PubMed: 31577901; DOI: 10.1021/acs.jmedchem.9b01104

実験手法

X-RAY DIFFRACTION (2.2 Å)