6O8B
Crystal structure of STING CTD in complex with TBK1
Summary for 6O8B
Entry DOI | 10.2210/pdb6o8b/pdb |
Descriptor | Stimulator of interferon genes protein, Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (3 entities in total) |
Functional Keywords | adaptor, kinase, complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 205461.57 |
Authors | |
Primary citation | Zhao, B.,Du, F.,Xu, P.,Shu, C.,Sankaran, B.,Bell, S.L.,Liu, M.,Lei, Y.,Gao, X.,Fu, X.,Zhu, F.,Liu, Y.,Laganowsky, A.,Zheng, X.,Ji, J.Y.,West, A.P.,Watson, R.O.,Li, P. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569:718-722, 2019 Cited by PubMed: 31118511DOI: 10.1038/s41586-019-1228-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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