6O70
Crystal structure of Csm6 H132A mutant in complex with cA4 by cocrystallization of cA4 and Csm6 H132A mutant
Summary for 6O70
Entry DOI | 10.2210/pdb6o70/pdb |
Descriptor | Csm6, 2',3'- cyclic AMP, 3'-O-[(R)-{[(2S,3aS,4S,6S,6aS)-6-(6-amino-9H-purin-9-yl)-2-hydroxy-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]adenosine, ... (4 entities in total) |
Functional Keywords | type iii-a crispr-cas system; csm6 h132a mutant in complex with ca4, immune system |
Biological source | Thermococcus onnurineus (strain NA1) |
Total number of polymer chains | 2 |
Total formula weight | 101431.33 |
Authors | Jia, N.,Patel, D.J. (deposition date: 2019-03-07, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Jia, N.,Jones, R.,Yang, G.,Ouerfelli, O.,Patel, D.J. CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity. Mol.Cell, 75:944-956.e6, 2019 Cited by PubMed: 31326273DOI: 10.1016/j.molcel.2019.06.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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