6O5X

Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with substrate analog CA-p2

Summary for 6O5X

Entry DOI	10.2210/pdb6o5x/pdb
Related PRD ID	PRD_000349
Descriptor	HIV-1 protease PR-S17, CHLORIDE ION, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, ... (5 entities in total)
Functional Keywords	hiv protease, hydrolase, viral protein
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	4
Total formula weight	45280.91
Authors	Agniswamy, J.,Wang, Y.-F.,Weber, I.T. (deposition date: 2019-03-04, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. Acs Omega, 4:8707-8719, 2019 Cited by PubMed: 31172041 DOI: 10.1021/acsomega.9b00683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation