6O5S
Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B
Summary for 6O5S
Entry DOI | 10.2210/pdb6o5s/pdb |
Related | 6o5r |
Descriptor | Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium, ... (4 entities in total) |
Functional Keywords | vx-phosphonylated, vx-hache, oxime reactivator, imidazole-based oxime, rs-170b, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 121620.85 |
Authors | Gerlits, O.,Kovalevsky, A.,Radic, Z. (deposition date: 2019-03-04, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Gerlits, O.,Kong, X.,Cheng, X.,Wymore, T.,Blumenthal, D.K.,Taylor, P.,Radic, Z.,Kovalevsky, A. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. J.Biol.Chem., 294:10607-10618, 2019 Cited by PubMed: 31138650DOI: 10.1074/jbc.RA119.008725 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.801 Å) |
Structure validation
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