6O5N

Tubulin-RB3_SLD-TTL in complex with compound 10ab

Summary for 6O5N

• Entry DOI: 10.2210/pdb6o5n/pdb
• Related: 6O5M
• Descriptor: Tubulin alpha-1B chain, [2-(4-methyl-1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)methanone, Tubulin beta-2B chain, ... (11 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cancer, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 264564.13

Authors

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-03-04, release date: 2019-07-10, Last modification date: 2024-03-13)

• Primary citation: Wang, Q.,Arnst, K.E.,Wang, Y.,Kumar, G.,Ma, D.,White, S.W.,Miller, D.D.,Li, W.,Li, W.; Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.; J.Med.Chem., 62:6734-6750, 2019; PubMed: 31251599; DOI: 10.1021/acs.jmedchem.9b00706

Experimental method

X-RAY DIFFRACTION (3.003 Å)