6O4W

Binary complex of native hAChE with Donepezil

Summary for 6O4W

DescriptorAcetylcholinesterase, GLYCEROL, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, ... (5 entities in total)
Functional Keywordshydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight122135.52
Authors
Gerlits, O.,Kovalevsky, A.,Radic, Z. (deposition date: 2019-03-01, release date: 2019-06-19, Last modification date: 2019-07-10)
Primary citation
Gerlits, O.,Ho, K.Y.,Cheng, X.,Blumenthal, D.,Taylor, P.,Kovalevsky, A.,Radic, Z.
A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.
Chem.Biol.Interact., 309:108698-108698, 2019
PubMed: 31176713 (PDB entries with the same primary citation)
DOI: 10.1016/j.cbi.2019.06.011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18630 1.1% 1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution