6O4L
Structure of ALDH7A1 mutant E399D complexed with NAD
Summary for 6O4L
Entry DOI | 10.2210/pdb6o4l/pdb |
Descriptor | Alpha-aminoadipic semialdehyde dehydrogenase, 1,2-ETHANEDIOL, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | aldehyde dehydrogenase, nad, oxidoreductase, lysine catabolism |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 225398.24 |
Authors | Tanner, J.J.,Korasick, D.A.,Laciak, A.R. (deposition date: 2019-02-28, release date: 2019-11-06, Last modification date: 2023-10-11) |
Primary citation | Laciak, A.R.,Korasick, D.A.,Gates, K.S.,Tanner, J.J. Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy. J. Inherit. Metab. Dis., 43:635-644, 2020 Cited by PubMed: 31652343DOI: 10.1002/jimd.12184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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