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6O2P

Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)

Summary for 6O2P
Entry DOI10.2210/pdb6o2p/pdb
EMDB information0611
DescriptorCystic fibrosis transmembrane conductance regulator, Unknown Peptide, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordsabc transporter, anion channel, cystic fibrosis, membrane protein, ivacaftor, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight178062.62
Authors
Liu, F.,Zhang, Z.,Chen, J.,Levit, A.,Shoichet, B. (deposition date: 2019-02-24, release date: 2019-06-26, Last modification date: 2021-08-25)
Primary citationLiu, F.,Zhang, Z.,Levit, A.,Levring, J.,Touhara, K.K.,Shoichet, B.K.,Chen, J.
Structural identification of a hotspot on CFTR for potentiation.
Science, 364:1184-1188, 2019
Cited by
PubMed: 31221859
DOI: 10.1126/science.aaw7611
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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