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6O23

Crystal structure of 2243 Fab in complex with circumsporozoite protein NANP5

6O23 の概要
エントリーDOI10.2210/pdb6o23/pdb
分子名称2243 Fab heavy chain, 2243 kappa light chain, Circumsporozoite protein, ... (7 entities in total)
機能のキーワードmalaria, antibody, immune system
由来する生物種Homo sapiens (Human)
詳細
タンパク質・核酸の鎖数5
化学式量合計98885.56
構造登録者
Scally, S.W.,Bosch, A.,Prieto, K.,Murugan, R.,Wardemann, H.,Julien, J.P. (登録日: 2019-02-22, 公開日: 2020-03-04, 最終更新日: 2024-11-06)
主引用文献Murugan, R.,Scally, S.W.,Costa, G.,Mustafa, G.,Thai, E.,Decker, T.,Bosch, A.,Prieto, K.,Levashina, E.A.,Julien, J.P.,Wardemann, H.
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.
Nat. Med., 26:1135-1145, 2020
Cited by
PubMed Abstract: The circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in animal models. However, the limited efficacy of the PfCSP-based vaccine RTS,S calls for a better understanding of the mechanisms driving the development of the most potent human PfCSP antibodies and identification of their target epitopes. By characterizing 200 human monoclonal PfCSP antibodies induced by sporozoite immunization, we establish that the most potent antibodies bind around a conserved (N/D)PNANPN(V/A) core. High antibody affinity to the core correlates with protection from parasitemia in mice and evolves around the recognition of NANP motifs. The data suggest that the rational design of a next-generation PfCSP vaccine that elicits high-affinity antibody responses against the core epitope will promote the induction of protective humoral immune responses.
PubMed: 32451496
DOI: 10.1038/s41591-020-0881-9
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2 Å)
構造検証レポート
Validation report summary of 6o23
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-06に公開中

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