6O21
Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor
Summary for 6O21
Entry DOI | 10.2210/pdb6o21/pdb |
Related PRD ID | PRD_001059 |
Descriptor | Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a, Trypsin inhibitor 1, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kallikrein-related peptidase 4, klk4, sunflower trypsin inhibitor, sfti, laskowski mechanism inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 25912.24 |
Authors | Ilyichova, O.V.,Buckle, A.M. (deposition date: 2019-02-22, release date: 2019-03-13, Last modification date: 2023-10-11) |
Primary citation | Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M. KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58:2524-2533, 2019 Cited by PubMed: 31058493DOI: 10.1021/acs.biochem.9b00191 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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