6O1V
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and GLPG1837
Summary for 6O1V
Entry DOI | 10.2210/pdb6o1v/pdb |
EMDB information | 0606 |
Descriptor | Cystic fibrosis transmembrane conductance regulator, Unknown Peptide, N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide, ... (7 entities in total) |
Functional Keywords | abc transporter, anion channel, cystic fibrosis, membrane protein, glpg1837, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 176415.82 |
Authors | Zhang, Z.,Liu, F.,Chen, J.,Levit, A.,Shoichet, B. (deposition date: 2019-02-21, release date: 2019-06-26, Last modification date: 2024-03-20) |
Primary citation | Liu, F.,Zhang, Z.,Levit, A.,Levring, J.,Touhara, K.K.,Shoichet, B.K.,Chen, J. Structural identification of a hotspot on CFTR for potentiation. Science, 364:1184-1188, 2019 Cited by PubMed: 31221859DOI: 10.1126/science.aaw7611 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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