6O1B

Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 1

Summary for 6O1B

Entry DOI	10.2210/pdb6o1b/pdb
Descriptor	Sterile alpha and TIR motif-containing protein 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	axon degeneration, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16569.01
Authors	Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Tiancong, Q.,Gilley, J.,Lai, J.,Gu, W.,Rank, M.,Casey, L.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. (deposition date: 2019-02-18, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citation	Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Qi, T.,Gilley, J.,Lai, J.S.,Rank, M.X.,Casey, L.W.,Gu, W.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. NAD+cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365:793-799, 2019 Cited by PubMed: 31439792 DOI: 10.1126/science.aax1911 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation