6O0S

Crystal structure of the tandem SAM domains from human SARM1

Summary for 6O0S

• Entry DOI: 10.2210/pdb6o0s/pdb
• Descriptor: Sterile alpha and TIR motif-containing protein 1 (1 entity in total)
• Functional Keywords: axon degeneration, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 162374.23

Authors

Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Tiancong, Q.,Gilley, J.,Lai, J.,Gu, W.,Rank, M.,Deerain, N.,Casey, L.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. (deposition date: 2019-02-17, release date: 2019-09-04, Last modification date: 2024-03-13)

• Primary citation: Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Qi, T.,Gilley, J.,Lai, J.S.,Rank, M.X.,Casey, L.W.,Gu, W.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B.; NAD+cleavage activity by animal and plant TIR domains in cell death pathways.; Science, 365:793-799, 2019; PubMed: 31439792; DOI: 10.1126/science.aax1911

Experimental method

X-RAY DIFFRACTION (2.7 Å)