6O0Q

Crystal structure of the TIR domain from human SARM1 in complex with ribose

6O0Q の概要

• エントリーDOI: 10.2210/pdb6o0q/pdb
• 分子名称: Sterile alpha and TIR motif-containing protein 1, beta-D-ribofuranose, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: axon degeneration, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33038.57

構造登録者

Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Tiancong, Q.,Gilley, J.,Lai, J.,Gu, W.,Rank, M.,Deerain, N.,Casey, L.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B. (登録日: 2019-02-17, 公開日: 2019-09-04, 最終更新日: 2024-03-13)

• 主引用文献: Horsefield, S.,Burdett, H.,Zhang, X.,Manik, M.K.,Shi, Y.,Chen, J.,Qi, T.,Gilley, J.,Lai, J.S.,Rank, M.X.,Casey, L.W.,Gu, W.,Ericsson, D.J.,Foley, G.,Hughes, R.O.,Bosanac, T.,von Itzstein, M.,Rathjen, J.P.,Nanson, J.D.,Boden, M.,Dry, I.B.,Williams, S.J.,Staskawicz, B.J.,Coleman, M.P.,Ve, T.,Dodds, P.N.,Kobe, B.; NAD+cleavage activity by animal and plant TIR domains in cell death pathways.; Science, 365:793-799, 2019; PubMed: 31439792; DOI: 10.1126/science.aax1911

実験手法

X-RAY DIFFRACTION (1.8 Å)