6NZW

LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state

Summary for 6NZW

• Entry DOI: 10.2210/pdb6nzw/pdb
• EMDB information: 0562
• Descriptor: Volume-regulated anion channel subunit LRRC8A, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid (3 entities in total)
• Functional Keywords: ion channel, volume-regulation, membrane protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 6
• Total formula weight: 585996.10

Authors

Kern, D.M.,Hite, R.K.,Brohawn, S.G. (deposition date: 2019-02-14, release date: 2019-02-27, Last modification date: 2019-12-18)

• Primary citation: Kern, D.M.,Oh, S.,Hite, R.K.,Brohawn, S.G.; Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.; Elife, 8:-, 2019; PubMed: 30775971; DOI: 10.7554/eLife.42636

Experimental method

ELECTRON MICROSCOPY (3.21 Å)