6NZT

Crystal structure of HCV NS3/4A protease in complex with voxilaprevir

Summary for 6NZT

Entry DOI	10.2210/pdb6nzt/pdb
Descriptor	HCV NS3/4A protease, Voxilaprevir, ZINC ION, ... (5 entities in total)
Functional Keywords	viral protease inhibitor, voxilaprevir, hepatitis c virus, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Hepatitis C virus
Total number of polymer chains	1
Total formula weight	22546.78
Authors	Appleby, T.C.,Taylor, J.G. (deposition date: 2019-02-14, release date: 2019-07-10, Last modification date: 2023-10-11)
Primary citation	Taylor, J.G.,Zipfel, S.,Ramey, K.,Vivian, R.,Schrier, A.,Karki, K.K.,Katana, A.,Kato, D.,Kobayashi, T.,Martinez, R.,Sangi, M.,Siegel, D.,Tran, C.V.,Yang, Z.Y.,Zablocki, J.,Yang, C.Y.,Wang, Y.,Wang, K.,Chan, K.,Barauskas, O.,Cheng, G.,Jin, D.,Schultz, B.E.,Appleby, T.,Villasenor, A.G.,Link, J.O. Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®. Bioorg.Med.Chem.Lett., 29:2428-2436, 2019 Cited by PubMed: 31133531 DOI: 10.1016/j.bmcl.2019.03.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation