6NY7

Crystal Structure of NDM-1 D199N with Compound 16

Summary for 6NY7

Entry DOI	10.2210/pdb6ny7/pdb
Descriptor	Carbapenem Hydrolyzing Class B Metallo beta lactamase NDM-1, ZINC ION, [(5,7-dibromo-2-oxo-1,2-dihydroquinolin-4-yl)methyl]phosphonic acid, ... (4 entities in total)
Functional Keywords	carbapenemase, phosphonate, inhibitor, complex, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	25129.47
Authors	Akhtar, A.,Chen, Y. (deposition date: 2019-02-11, release date: 2019-09-25, Last modification date: 2023-10-11)
Primary citation	Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651 DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation