6NY4
Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
Summary for 6NY4
Entry DOI | 10.2210/pdb6ny4/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33594.39 |
Authors | Sack, J.S. (deposition date: 2019-02-11, release date: 2019-05-22, Last modification date: 2024-03-13) |
Primary citation | Spergel, S.H.,Mertzman, M.E.,Kempson, J.,Guo, J.,Stachura, S.,Haque, L.,Lippy, J.S.,Zhang, R.F.,Galella, M.,Pitt, S.,Shen, G.,Fura, A.,Gillooly, K.,McIntyre, K.W.,Tang, V.,Tokarski, J.,Sack, J.S.,Khan, J.,Carter, P.H.,Barrish, J.C.,Nadler, S.G.,Salter-Cid, L.M.,Schieven, G.L.,Wrobleski, S.T.,Pitts, W.J. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. Acs Med.Chem.Lett., 10:306-311, 2019 Cited by PubMed: 30891131DOI: 10.1021/acsmedchemlett.8b00508 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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