6NWS
RORgamma Ligand Binding Domain
Summary for 6NWS
Entry DOI | 10.2210/pdb6nws/pdb |
Descriptor | Nuclear receptor ROR-gamma, 2-chloro-6-fluoro-N-(1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indol-6-yl)benzamide (3 entities in total) |
Functional Keywords | orphan nuclear receptor, synthetic modulator, chemical probe, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30581.74 |
Authors | Strutzenberg, T.S.,Park, H.J.,Griffin, P.R. (deposition date: 2019-02-07, release date: 2019-07-10, Last modification date: 2023-10-11) |
Primary citation | Strutzenberg, T.S.,Garcia-Ordonez, R.D.,Novick, S.J.,Park, H.,Chang, M.R.,Doebellin, C.,He, Y.,Patouret, R.,Kamenecka, T.M.,Griffin, P.R. HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists. Elife, 8:-, 2019 Cited by PubMed: 31172947DOI: 10.7554/eLife.47172 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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