6NW2

Structure of human RIPK1 kinase domain in complex with compound 11

Summary for 6NW2

• Entry DOI: 10.2210/pdb6nw2/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, (5R)-5-methyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide (3 entities in total)
• Functional Keywords: rip1, kinase, rip, rip1k ripk1, immune system, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71558.47

Authors

Fong, R.,Lupardus, P.J. (deposition date: 2019-02-05, release date: 2019-05-01, Last modification date: 2024-03-13)

• Primary citation: Hamilton, G.L.,Chen, H.,Deshmukh, G.,Eigenbrot, C.,Fong, R.,Johnson, A.,Kohli, P.B.,Lupardus, P.J.,Liederer, B.M.,Ramaswamy, S.,Wang, H.,Wang, J.,Xu, Z.,Zhu, Y.,Vucic, D.,Patel, S.; Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.; Bioorg.Med.Chem.Lett., 29:1497-1501, 2019; PubMed: 31000154; DOI: 10.1016/j.bmcl.2019.04.014

Experimental method

X-RAY DIFFRACTION (2 Å)