6NVI

FGFR4 complex with N-(3-chloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-5-fluorophenyl)acrylamide

Summary for 6NVI

• Entry DOI: 10.2210/pdb6nvi/pdb
• Descriptor: Fibroblast growth factor receptor 4, N-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34493.05

Authors

Lin, X.,Smaill, J.B.,Squire, C.J.,Yosaatmadja, Y. (deposition date: 2019-02-05, release date: 2019-07-10, Last modification date: 2023-10-11)

• Primary citation: Lin, X.,Yosaatmadja, Y.,Kalyukina, M.,Middleditch, M.J.,Zhang, Z.,Lu, X.,Ding, K.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.; Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.; Acs Med.Chem.Lett., 10:1180-1186, 2019; PubMed: 31413803; DOI: 10.1021/acsmedchemlett.9b00196

Experimental method

X-RAY DIFFRACTION (2.117 Å)