6NUQ
Stat3 Core in complex with compound SI109
Summary for 6NUQ
Entry DOI | 10.2210/pdb6nuq/pdb |
Descriptor | Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name) (3 entities in total) |
Functional Keywords | stat3, activator, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 65253.75 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2019-02-01, release date: 2019-12-04, Last modification date: 2023-10-11) |
Primary citation | Bai, L.,Zhou, H.,Xu, R.,Zhao, Y.,Chinnaswamy, K.,McEachern, D.,Chen, J.,Yang, C.Y.,Liu, Z.,Wang, M.,Liu, L.,Jiang, H.,Wen, B.,Kumar, P.,Meagher, J.L.,Sun, D.,Stuckey, J.A.,Wang, S. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell, 36:498-511.e17, 2019 Cited by PubMed: 31715132DOI: 10.1016/j.ccell.2019.10.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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