6NT7

Cryo-EM structure of full-length chicken STING in the cGAMP-bound dimeric state

Summary for 6NT7

• Entry DOI: 10.2210/pdb6nt7/pdb
• EMDB information: 0504
• Descriptor: Stimulator of interferon genes protein, cGAMP (2 entities in total)
• Functional Keywords: er, membrane, adaptor, immune system
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 89088.55

Authors

Shang, G.,Zhang, C.,Chen, Z.J.,Bai, X.,Zhang, X. (deposition date: 2019-01-28, release date: 2019-03-06, Last modification date: 2024-03-20)

• Primary citation: Shang, G.,Zhang, C.,Chen, Z.J.,Bai, X.C.,Zhang, X.; Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.; Nature, 567:389-393, 2019; PubMed: 30842659; DOI: 10.1038/s41586-019-0998-5

Experimental method

ELECTRON MICROSCOPY (4 Å)