6NR4

Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium

Summary for 6NR4

Entry DOI	10.2210/pdb6nr4/pdb
EMDB information	0487 0488 0489
Descriptor	Transient receptor potential cation channel subfamily M member 8 (1 entity in total)
Functional Keywords	ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, calcium-permeable channel, cooling agent, transport protein
Biological source	Ficedula albicollis (Collared flycatcher) More
Total number of polymer chains	4
Total formula weight	518771.75
Authors	Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (deposition date: 2019-01-22, release date: 2019-02-20, Last modification date: 2019-12-18)
Primary citation	Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science, 363:-, 2019 Cited by PubMed: 30733385 DOI: 10.1126/science.aav9334 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.3 Å)

Structure validation