6NQ2
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Summary for 6NQ2
Entry DOI | 10.2210/pdb6nq2/pdb |
EMDB information | 0477 0478 0479 |
Descriptor | Two pore calcium channel protein 2, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (2 entities in total) |
Functional Keywords | channel, lysosome, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 172836.79 |
Authors | |
Primary citation | She, J.,Zeng, W.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y. Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8:-, 2019 Cited by PubMed: 30860481DOI: 10.7554/eLife.45222 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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