6NPY

Cryo-EM structure of NLRP3 bound to NEK7

Summary for 6NPY

Entry DOI	10.2210/pdb6npy/pdb
EMDB information	0476
Descriptor	NACHT, LRR and PYD domains-containing protein 3, Protein kinase R,Serine/threonine-protein kinase Nek7, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	inflammasome, activator, biological process immunity, inflammatory response, innate immunity, transcription, transcription regulation ligand, atp binding, nucleotide binding, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	150333.33
Authors	Sharif, H.,Wang, L.,Wang, W.L.,Wu, H. (deposition date: 2019-01-18, release date: 2019-06-19, Last modification date: 2024-03-20)
Primary citation	Sharif, H.,Wang, L.,Wang, W.L.,Magupalli, V.G.,Andreeva, L.,Qiao, Q.,Hauenstein, A.V.,Wu, Z.,Nunez, G.,Mao, Y.,Wu, H. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature, 570:338-343, 2019 Cited by PubMed: 31189953 DOI: 10.1038/s41586-019-1295-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation