6NPY

Cryo-EM structure of NLRP3 bound to NEK7

6NPY の概要

• エントリーDOI: 10.2210/pdb6npy/pdb
• EMDBエントリー: 0476
• 分子名称: NACHT, LRR and PYD domains-containing protein 3, Protein kinase R,Serine/threonine-protein kinase Nek7, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: inflammasome, activator, biological process immunity, inflammatory response, innate immunity, transcription, transcription regulation ligand, atp binding, nucleotide binding, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 150333.33

構造登録者

Sharif, H.,Wang, L.,Wang, W.L.,Wu, H. (登録日: 2019-01-18, 公開日: 2019-06-19, 最終更新日: 2024-03-20)

• 主引用文献: Sharif, H.,Wang, L.,Wang, W.L.,Magupalli, V.G.,Andreeva, L.,Qiao, Q.,Hauenstein, A.V.,Wu, Z.,Nunez, G.,Mao, Y.,Wu, H.; Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.; Nature, 570:338-343, 2019; PubMed: 31189953; DOI: 10.1038/s41586-019-1295-z

実験手法

ELECTRON MICROSCOPY (3.8 Å)