6NPI

Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments

Summary for 6NPI

• Entry DOI: 10.2210/pdb6npi/pdb
• Descriptor: Epstein-Barr nuclear antigen 1, 2-pyrrol-1-ylbenzoic acid, ({2-[(4-bromo-5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl}sulfanyl)acetic acid, ... (4 entities in total)
• Functional Keywords: ebna1, dna binding protein, epstein-barr virus, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Epstein-Barr virus (strain B95-8) (HHV-4)
• Total number of polymer chains: 2
• Total formula weight: 31109.69

Authors

Messick, T.E. (deposition date: 2019-01-17, release date: 2019-03-20, Last modification date: 2023-10-11)

• Primary citation: Messick, T.E.,Smith, G.R.,Soldan, S.S.,McDonnell, M.E.,Deakyne, J.S.,Malecka, K.A.,Tolvinski, L.,van den Heuvel, A.P.J.,Gu, B.W.,Cassel, J.A.,Tran, D.H.,Wassermann, B.R.,Zhang, Y.,Velvadapu, V.,Zartler, E.R.,Busson, P.,Reitz, A.B.,Lieberman, P.M.; Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.; Sci Transl Med, 11:-, 2019; PubMed: 30842315; DOI: 10.1126/scitranslmed.aau5612

Experimental method

X-RAY DIFFRACTION (1.501 Å)