6NPI
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
6NPI の概要
エントリーDOI | 10.2210/pdb6npi/pdb |
分子名称 | Epstein-Barr nuclear antigen 1, 2-pyrrol-1-ylbenzoic acid, ({2-[(4-bromo-5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl}sulfanyl)acetic acid, ... (4 entities in total) |
機能のキーワード | ebna1, dna binding protein, epstein-barr virus, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
由来する生物種 | Epstein-Barr virus (strain B95-8) (HHV-4) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 31109.69 |
構造登録者 | |
主引用文献 | Messick, T.E.,Smith, G.R.,Soldan, S.S.,McDonnell, M.E.,Deakyne, J.S.,Malecka, K.A.,Tolvinski, L.,van den Heuvel, A.P.J.,Gu, B.W.,Cassel, J.A.,Tran, D.H.,Wassermann, B.R.,Zhang, Y.,Velvadapu, V.,Zartler, E.R.,Busson, P.,Reitz, A.B.,Lieberman, P.M. Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth. Sci Transl Med, 11:-, 2019 Cited by PubMed: 30842315DOI: 10.1126/scitranslmed.aau5612 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.501 Å) |
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