6NP9

PD-L1 IgV domain V76T with fragment

Summary for 6NP9

• Entry DOI: 10.2210/pdb6np9/pdb
• Descriptor: Programmed cell death 1 ligand 1, SULFATE ION (3 entities in total)
• Functional Keywords: fragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14734.71

Authors

Zhao, B.,Perry, E. (deposition date: 2019-01-17, release date: 2019-02-20, Last modification date: 2023-10-11)

• Primary citation: Perry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.; Fragment-based screening of programmed death ligand 1 (PD-L1).; Bioorg. Med. Chem. Lett., 29:786-790, 2019; PubMed: 30728114; DOI: 10.1016/j.bmcl.2019.01.028

Experimental method

X-RAY DIFFRACTION (1.27 Å)