6NP2

AAC-VIa bound to Sisomicin

Summary for 6NP2

Entry DOI	10.2210/pdb6np2/pdb
Descriptor	Aminoglycoside N(3)-acetyltransferase, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	antibiotic modifying enzyme, substrate selectivity, antibiotic, transferase
Biological source	Enterobacter cloacae
Total number of polymer chains	1
Total formula weight	29206.22
Authors	Kumar, P.,Cuneo, M.J. (deposition date: 2019-01-17, release date: 2019-09-25, Last modification date: 2023-10-11)
Primary citation	Kumar, P.,Agarwal, P.K.,Waddell, M.B.,Mittag, T.,Serpersu, E.H.,Cuneo, M.J. Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58:16260-16266, 2019 Cited by PubMed: 31515870 DOI: 10.1002/anie.201908535 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation