6NOS

PD-L1 IgV domain V76T with fragment

6NOS の概要

分子名称Programmed cell death 1 ligand 1, 1-[5-(3,5-dichlorophenyl)furan-2-yl]-N-methylmethanamine (2 entities in total)
機能のキーワードfragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計29359.36
構造登録者
Zhao, B.,Perry, E. (登録日: 2019-01-16, 公開日: 2019-02-20, 最終更新日: 2019-03-06)
主引用文献
Perry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.
Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29:786-790, 2019
PubMed: 30728114 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2019.01.028
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.701 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.279120 3.7%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード