6NO9

PIM1 in complex with Cpd16 (5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)

6NO9 の概要

• エントリーDOI: 10.2210/pdb6no9/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, GLYCEROL, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32265.33

構造登録者

Murray, J.M.,Noland, C. (登録日: 2019-01-15, 公開日: 2019-02-27, 最終更新日: 2023-10-11)

• 主引用文献: Wang, X.,Blackaby, W.,Allen, V.,Chan, G.K.Y.,Chang, J.H.,Chiang, P.C.,Diene, C.,Drummond, J.,Do, S.,Fan, E.,Harstad, E.B.,Hodges, A.,Hu, H.,Jia, W.,Kofie, W.,Kolesnikov, A.,Lyssikatos, J.P.,Ly, J.,Matteucci, M.,Moffat, J.G.,Munugalavadla, V.,Murray, J.,Nash, D.,Noland, C.L.,Del Rosario, G.,Ross, L.,Rouse, C.,Sharpe, A.,Slaga, D.,Sun, M.,Tsui, V.,Wallweber, H.,Yu, S.F.,Ebens, A.J.; Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.; J. Med. Chem., 62:2140-2153, 2019; PubMed: 30715878; DOI: 10.1021/acs.jmedchem.8b01857

実験手法

X-RAY DIFFRACTION (1.712 Å)