6NO8

PIM1 in complex with Cpd9 ((R)-5-amino-N-(3-(4-aminoazepan-1-yl)-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)

6NO8 の概要

• エントリーDOI: 10.2210/pdb6no8/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 5-amino-N-{5-[(4S)-4-aminoazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32060.27

構造登録者

Murray, J.M.,wang, X. (登録日: 2019-01-15, 公開日: 2019-11-27, 最終更新日: 2023-10-11)

• 主引用文献: Murray, J.M.,Wang, X.; Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma; To be published,

実験手法

X-RAY DIFFRACTION (2.377 Å)