6NNV

PD-L1 IgV domain complex with macro-cyclic peptide

6NNV の概要

分子名称Programmed cell death 1 ligand 1, macrocyclic peptide (3 entities in total)
機能のキーワードfragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system
由来する生物種Homo sapiens (Human)
詳細
ポリマー鎖数8
分子量合計65583.27
構造登録者
Zhao, B.,Perry, E. (登録日: 2019-01-15, 公開日: 2019-02-20, 最終更新日: 2019-03-06)
主引用文献
Perry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.
Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29:786-790, 2019
PubMed: 30728114 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2019.01.028
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.92 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2567 1.0% 1.7% 1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード